Alcofan 50 mg (Ketoprofen) – Comprehensive Guide to Uses, Dosage, Side Effects, and Safety

Alcofan 50 mg is a non-steroidal anti-inflammatory drug (NSAID) that contains Ketoprofen, a powerful medication commonly prescribed for managing various inflammatory and pain-related disorders. This medication is especially effective in providing relief from joint pain, inflammation, and musculoskeletal conditions, improving patients' quality of life and mobility.

1. What is Alcofan 50 mg?

Alcofan 50 mg contains Ketoprofen 50 mg, a proven NSAID that works by inhibiting the cyclooxygenase (COX) enzymes, which are responsible for the production of prostaglandins—substances that mediate pain, fever, and inflammation. This inhibition reduces swelling, pain, and stiffness associated with various conditions.

Pharmaceutical Form:

Hard gelatin capsules, designed for oral administration.

2. Key Medical Uses of Alcofan 50 mg

Alcofan is indicated for the treatment of a wide range of acute and chronic inflammatory conditions, particularly in the musculoskeletal system. Below are the approved therapeutic indications:

Rheumatoid arthritis
Osteoarthritis
Ankylosing spondylitis
Acute joint and periarticular disorders (e.g., bursitis, capsulitis, synovitis, tendinitis)
Cervical spondylitis
Low back pain (including lumbago, sciatica, fibrositis)
Acute gout attacks
Dysmenorrhoea (painful menstruation)
Post-operative orthopedic pain and inflammation
General musculoskeletal pain

How It Helps:

Alcofan does not cure the underlying disease but significantly alleviates pain and inflammation, allowing for greater mobility and independence in daily activities.

3. Dosage and Method of Administration

General Dosage Guidelines:

Initial dosage: 50–100 mg twice daily (morning and evening).
Maximum daily dose: 200 mg.
Treatment should be tailored individually based on the patient’s weight, severity of symptoms, and tolerance.

Best Practices for Administration:

Always take capsules with food or milk to reduce gastrointestinal side effects.
For long-term use, the lowest effective dose should be maintained.
Adjustments should be made according to patient response—lower dosages for chronic conditions, and higher dosages for acute flare-ups.

Special Populations:

Elderly: Start with the lowest effective dose. Elderly patients have an increased risk of gastrointestinal bleeding and cardiovascular events.
Children: Not recommended; pediatric dosage has not been established.

4. Contraindications: When Not to Use Alcofan

Patients should not take Alcofan if they have:

Allergy or hypersensitivity to Ketoprofen, aspirin, or other NSAIDs
History of anaphylaxis, asthmatic attacks, or urticaria due to NSAIDs
Active or previous peptic ulcers
Gastrointestinal bleeding or perforation
Severe heart failure
Severe liver or kidney dysfunction
Third trimester of pregnancy
Pediatric patients (due to lack of safety data)

Important: Alcofan can cause life-threatening allergic reactions in sensitive individuals. Always disclose your medical history to your healthcare provider.

5. Special Warnings and Precautions

Cardiovascular Risks:

NSAIDs, including Ketoprofen, may increase the risk of:

Heart attacks (myocardial infarction)
Stroke
Thrombotic events

These risks are higher with long-term use and in patients with existing heart conditions. Alcofan is not recommended for pain management after coronary artery bypass graft (CABG) surgery.

Gastrointestinal Risks:

NSAIDs may cause:

Ulceration
Bleeding
Perforation of the stomach or intestines

These effects can occur without warning and may be fatal, especially in the elderly.

Other Precautions:

Monitor for renal function, liver enzymes, and blood pressure in long-term therapy.
Avoid combining with alcohol or other NSAIDs to reduce GI risks.

6. Mechanism of Action: How Ketoprofen Works

Ketoprofen exerts its effect by:

Blocking COX-1 and COX-2 enzymes, leading to reduced synthesis of prostaglandins
Alleviating inflammation, swelling, and pain at the affected site
Providing analgesic (pain-relieving) and antipyretic (fever-reducing) benefits

This dual action makes it particularly effective in treating arthritis-related pain and inflammation.

7. Common Side Effects of Alcofan

While many patients tolerate Alcofan well, common side effects may include:

Gastrointestinal discomfort (nausea, heartburn, abdominal pain)
Headache or dizziness
Diarrhea or constipation
Skin rashes
Edema (fluid retention)

In rare cases, serious adverse effects like GI bleeding, kidney damage, and allergic reactions can occur. Promptly report any unusual symptoms to a healthcare provider.

8. Drug Interactions

Alcofan may interact with:

Anticoagulants (e.g., warfarin) – increased bleeding risk
Antihypertensives (ACE inhibitors, diuretics) – reduced effectiveness
Other NSAIDs or corticosteroids – higher GI toxicity
Lithium – increased lithium levels and potential toxicity
Methotrexate – enhanced toxicity

Always inform your doctor of all medications you’re taking, including over-the-counter drugs and supplements.

9. Safe Use Guidelines

To use Alcofan safely and effectively:

Follow the prescribed dosage strictly
Take with meals to minimize GI issues
Do not self-medicate, especially with other painkillers
Avoid alcohol during treatment
Report any side effects promptly

10. Storage and Handling

Store below 25°C (77°F)
Keep away from direct sunlight and moisture
Keep out of reach of children

Do not use the medication past its expiry date and consult a pharmacist for safe disposal.

✅ Frequently Asked Questions (FAQs)

1. What is Alcofan 50 mg used for?

Alcofan 50 mg is primarily used to treat inflammatory conditions such as arthritis, muscle pain, and joint disorders. It is effective in relieving pain, reducing swelling, and improving joint function in chronic conditions like rheumatoid arthritis and osteoarthritis.

Additionally, it’s prescribed for acute flare-ups, including gout, post-operative pain, and menstrual cramps. Its powerful anti-inflammatory effects make it a common choice for both short-term and long-term pain management. Although it helps manage symptoms, it does not cure the underlying disease. Always use it as prescribed by a healthcare provider.

2. Is Alcofan safe for long-term use?

Alcofan can be used long-term but should be taken with medical supervision due to its potential gastrointestinal and cardiovascular risks. Long-term use may increase the chances of ulcers, bleeding, and heart problems, especially in older adults.

To minimize risks, doctors usually prescribe the lowest effective dose and monitor patients regularly. Patients with chronic conditions may benefit from periodic dosage adjustments. Lifestyle modifications and protective medications (like proton pump inhibitors) may be recommended alongside Alcofan. Always follow up regularly with your healthcare provider.

3. Can I take Alcofan on an empty stomach?

It is not advisable to take Alcofan on an empty stomach due to the risk of gastric irritation. NSAIDs like Ketoprofen can damage the stomach lining if taken without food, increasing the chance of ulcers and bleeding.

To reduce this risk, take Alcofan with food, milk, or directly after meals. If you experience any abdominal discomfort or notice blood in stools, seek immediate medical attention. Do not combine it with alcohol, as this can further irritate the stomach. Always follow your physician’s instructions for safe use.

4. Is Alcofan safe during pregnancy?

Alcofan is not recommended during pregnancy, especially in the third trimester, due to risks to both the mother and fetus. NSAIDs may cause premature closure of the ductus arteriosus, delayed labor, and bleeding complications during delivery.

During the first two trimesters, Alcofan should only be used if absolutely necessary and under medical guidance. Alternative pain management options are usually preferred during pregnancy. Always consult your obstetrician before taking any medications. Do not self-prescribe Alcofan if you are pregnant or planning pregnancy.

5. Can I take Alcofan with other painkillers?

It is generally not recommended to take Alcofan with other NSAIDs like ibuprofen or aspirin, as it increases the risk of gastrointestinal and kidney damage. However, it may sometimes be combined with acetaminophen (paracetamol) for enhanced pain relief under medical supervision.

Always discuss all medications with your doctor before combining them. Inform your physician about any over-the-counter drugs or herbal supplements. Combining drugs without guidance can lead to severe side effects or drug interactions. Always err on the side of caution.

6. How quickly does Alcofan start working?

Alcofan typically begins to work within 30 to 60 minutes after ingestion, with its peak effect observed in 1 to 2 hours. Its anti-inflammatory and analgesic effects can last up to 6 to 8 hours, depending on the dose and individual response.

Patients may notice significant relief from joint stiffness, pain, and swelling within a few days of consistent use. For chronic conditions, full benefits may take several weeks. Consistent use as prescribed yields the best results. Avoid skipping doses or doubling them without guidance.

7. Can elderly patients take Alcofan?

Yes, but with extreme caution. Elderly patients are more prone to side effects such as gastrointestinal bleeding, kidney problems, and cardiovascular issues from NSAID use.

Doctors often recommend starting with a lower dose and using the medication for the shortest possible duration. Regular monitoring is essential for blood pressure, kidney function, and signs of bleeding. Protective medications may also be prescribed. Elderly patients should have frequent check-ups while on Alcofan.

8. What should I do if I miss a dose of Alcofan?

If you miss a dose, take it as soon as you remember. If it’s almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.

Do not double the dose to catch up, as this can increase the risk of side effects. Setting reminders can help prevent missed doses. Consult your doctor if you miss doses frequently. Consistency is key to effective treatment.

9. How should I store Alcofan?

Alcofan should be stored in a cool, dry place, away from direct sunlight and moisture. Keep it at room temperature (below 25°C) and ensure the packaging is tightly closed.

Store it out of reach of children to prevent accidental ingestion. Do not use the capsules after the expiry date printed on the label. Consult a pharmacist for proper disposal if needed. Never flush medication down the toilet.

10. Is there a generic version of Alcofan?

Yes, the generic name of Alcofan is Ketoprofen, which is available in various strengths and formulations. Generic versions are usually more affordable and equally effective when manufactured by reputable companies.

Always ensure the generic product is approved by your local regulatory authority. Consult your doctor or pharmacist to determine if switching to a generic is appropriate for you. Never change brands without medical consultation. Efficacy and tolerability should be reviewed upon switching.

Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult your physician or healthcare provider for personalized recommendations.

Sources and References

Alcofan 50 mg capsules box. — Image showing Alcofan 50 mg packaging, a medicinal product for pain relief, anti-inflammatory, and fever-reducing.

About the Author

Dr. Ahmad Baker, PharmD

He is a senior pharmacist and health educator with extensive experience in the Middle East and North Africa region. Through his writing, Dr. Ahmad aims to empower communities by providing reliable, evidence-based health information. With expertise in clinical pharmacy and regulatory affairs, he strives to offer unique insights into healthcare and simplify complex medical concepts, making them accessible to everyone.

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