Zetamibe Tablets: Ezetimibe for Cholesterol Reduction

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Composition:

Each scored tablet contains: Ezetimibe 10 mg.

Properties:

Ezetimibe appears to act at the brush border of the small intestine and inhibits the intestinal absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver. This causes a reduction of hepatic cholesterol stores and an increase in clearance of cholesterol from the blood. Zetamibe reduces total-C, LDL-C, Apo B, and TG, and increases HDL-C in patients with hypercholesterolemia. Administration of Zetamibe with an HMG-CoA reductase inhibitor shows better results than either treatment alone.

Indications:

  • Primary hypercholesterolemia (heterozygous familial and nonfamilial), as monotherapy or in combination with an HMG-CoA reductase inhibitor to reduce elevated cholesterol, low-density lipoproteins, and triglycerides, in adjunction to diet.
  • In patients with homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering treatments.

Dosage Administration:

Generally, the recommended dose is one tablet of Zetamibe once daily, with or without food. Zetamibe may be administered with an HMG-CoA reductase inhibitor (at the same time of the day) for incremental effect.

Contra Indications:

  • Hypersensitivity to any component of this medication.
  • The use of Zetamibe with HMG-CoA reductase inhibitors is contraindicated with active liver disease or unexplained persistent elevations of serum transaminases.

Side Effects:

The Drug is generally well tolerated.

Packing:

Box contains 10 scored tablets in one strip.

Zetamibe is a product manufactured by Adwia Pharmaceuticals Industries. Adwia is a leading Egyptian company founded in 1984 with a mission to bring the latest technologies and the highest available know-how to the market. They are committed to innovation and care and have a proven track record of success. For more information about Adwia Pharmaceuticals Industries, please visit their website or contact them directly.

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