Itranox (Itraconazole) is a synthetic broad-spectrum antifungal

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Composition:

Each capsule contains: 100mg of Itraconazole.

Properties:

Itraconazole, a synthetic broad-spectrum antifungal agent, combats infections caused by dermatophytes, yeasts, candida, aspergillus, cladosporium spp, and other yeast & fungi. The bioavailability is at its maximum when the capsules are taken immediately after a full meal. The absorption of Itraconazole in keratinous tissues, especially the skin, is up to 4 times higher than in plasma.

Indications:

  • Gynecological indications: Vulvovaginal candidiasis.
  • Dermatological indications: Pityriasis versicolor, dermatomycosis, fungal keratitis, and oral candidiasis.

Dosage Administration:

  • Onychomycosis: A pulse treatment consists of taking 2 capsules (200 mg) twice daily for one week, followed by a 3-week drug-free interval. Two pulse treatments are recommended for finger nail infections, and three pulse treatments for toe nail infections.
  • Tinea corporis-T.mannum: Take 2 capsules (200 mg) once daily for 7 days.
  • Tinea pedis: Take 2 capsules (200 mg) daily for 7 days.
  • Pityriasis versicolor: Take 2 capsules (200 mg) once daily for 7 days.
  • Fungal keratitis: Take 2 capsules (200 mg) once daily for 21 days.
  • Oral Candidiasis: Take 1 capsule (100 mg) daily for 15 days.
  • Vulvovaginal Candidiasis: Take 2 capsules (200 mg) morning & evening for 1 day.
  • Itraconazole should be taken after a full meal to ensure optimal absorption.
  • For immunocompromised patients e.g. neutropenic, AIDS or organ transplant patients, the dose may be doubled.

Contra Indications:

  • Hypersensitivity to the drug or its excipients.
  • Pregnant women.

Precautions Warnings:

Patients with liver & renal impairment should monitor the liver & kidney functions if therapy with Itraconazole (more than one month) is prolonged. Interactions:

  • Terfenadine, Astemizole, Enzyme-inducing drugs such as phenytoin, and rifampicin reduce the oral bioavailability.
  • The dose of oral anticoagulants, digoxin, cyclosporin, calcium channel blockers, and quinidine should be reduced when taken concomitantly with Itraconazole.

Side Effects:

The most common are: dyspepsia, nausea, abdominal pain, and constipation.

Packing:

  • Box containing 3 blisters, each containing 5 capsules.
  • Box containing 1 blister, each containing 4 capsules.
Itraconazole is a product manufactured by Adwia Pharmaceuticals Industries. Adwia is a leading Egyptian company founded in 1984 with a mission to bring the latest technologies and the highest available know-how to the market. They are committed to innovation and care and have a proven track record of success. For more information about Adwia Pharmaceuticals Industries, please visit their website or contact them directly.

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