Itranox (Itraconazole) is a synthetic broad-spectrum antifungal

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Composition:

Each capsule contains: 100mg of Itraconazole.

Properties:

Itraconazole, a synthetic broad-spectrum antifungal agent, combats infections caused by dermatophytes, yeasts, candida, aspergillus, cladosporium spp, and other yeast & fungi. The bioavailability is at its maximum when the capsules are taken immediately after a full meal. The absorption of Itraconazole in keratinous tissues, especially the skin, is up to 4 times higher than in plasma.

Indications:

  • Gynecological indications: Vulvovaginal candidiasis.
  • Dermatological indications: Pityriasis versicolor, dermatomycosis, fungal keratitis, and oral candidiasis.

Dosage Administration:

  • Onychomycosis: A pulse treatment consists of taking 2 capsules (200 mg) twice daily for one week, followed by a 3-week drug-free interval. Two pulse treatments are recommended for finger nail infections, and three pulse treatments for toe nail infections.
  • Tinea corporis-T.mannum: Take 2 capsules (200 mg) once daily for 7 days.
  • Tinea pedis: Take 2 capsules (200 mg) daily for 7 days.
  • Pityriasis versicolor: Take 2 capsules (200 mg) once daily for 7 days.
  • Fungal keratitis: Take 2 capsules (200 mg) once daily for 21 days.
  • Oral Candidiasis: Take 1 capsule (100 mg) daily for 15 days.
  • Vulvovaginal Candidiasis: Take 2 capsules (200 mg) morning & evening for 1 day.
  • Itraconazole should be taken after a full meal to ensure optimal absorption.
  • For immunocompromised patients e.g. neutropenic, AIDS or organ transplant patients, the dose may be doubled.

Contra Indications:

  • Hypersensitivity to the drug or its excipients.
  • Pregnant women.

Precautions Warnings:

Patients with liver & renal impairment should monitor the liver & kidney functions if therapy with Itraconazole (more than one month) is prolonged. Interactions:

  • Terfenadine, Astemizole, Enzyme-inducing drugs such as phenytoin, and rifampicin reduce the oral bioavailability.
  • The dose of oral anticoagulants, digoxin, cyclosporin, calcium channel blockers, and quinidine should be reduced when taken concomitantly with Itraconazole.

Side Effects:

The most common are: dyspepsia, nausea, abdominal pain, and constipation.

Packing:

  • Box containing 3 blisters, each containing 5 capsules.
  • Box containing 1 blister, each containing 4 capsules.
Itraconazole is a product manufactured by Adwia Pharmaceuticals Industries. Adwia is a leading Egyptian company founded in 1984 with a mission to bring the latest technologies and the highest available know-how to the market. They are committed to innovation and care and have a proven track record of success. For more information about Adwia Pharmaceuticals Industries, please visit their website or contact them directly.
 
   
     

About the Author

     

Dr. Ahmad Baker, PharmD

     

He is a senior pharmacist and health educator with extensive experience in the Middle East and North Africa region. Through his writing, Dr. Ahmad aims to empower communities by providing reliable, evidence-based health information. With expertise in clinical pharmacy and regulatory affairs, he strives to offer unique insights into healthcare and simplify complex medical concepts, making them accessible to everyone.

   
   
      Dr. Ahmad Baker    
 
      
   

Legal Disclaimer

   

The information provided in this blog is for educational purposes only and is not a substitute for professional medical advice. We do not guarantee the accuracy or completeness of information regarding medications or medical products, and official sources should be verified before making any decisions. By using this blog, you agree to assume personal responsibility for relying on the information provided.

 

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