Adwipril Tablets: Essential Hypertension Treatment

Composition:

Each Adwipril tablet contains 4 mg of Perindopril terbutylamine.

Properties:

Perindopril lowers blood pressure through the inhibition of ACE activity. ACE is an enzyme that catalyzes the conversion of the inactive angiotensin I to the vasoconstrictor angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II, leading to decreased vasoconstriction, increased plasma renin activity, and decreased aldosterone secretion.

Indications:

For the treatment of patients with essential hypertension. May be used alone or given with other classes of antihypertensives, especially thiazide diuretics.

Dosage Administration:

Use in Uncomplicated Hypertensive Patients:

The initial dose is 4 mg once a day. The dosage may be titrated upward until blood pressure, when measured just before the next dose, is controlled. The usual maintenance dose range is 4 to 8 mg administered as a single daily dose. Adwipril Tablets may also be administered in two divided doses.

Use in the Elderly Patients:

As in younger patients, the recommended initial daily dosage of ADWIPRIL Tablets for the elderly (>65 years) is 4 mg daily, given in one or two divided doses. The daily doses may be titrated upwards until blood pressure is controlled.

Use in Concomitant Diuretics:

To reduce the likelihood of hypotension, the diuretic should be discontinued 2 to 3 days prior to the beginning of Adwipril Tablets therapy. If the diuretic cannot be discontinued, an initial dose of 2 to 4 mg daily in one or in two divided doses should be used with careful medical supervision for several hours until blood pressure has stabilized.

Contra Indications:

• Hypersensitivity to this product or to any other ACE inhibitor.
• In patients with a history of angioedema related to previous treatment with an ACE inhibitor.

Precautions and Warnings:

• Impaired Renal Function.
• Hypertensive Patients with Congestive Heart FailureHypertensive Patients with unilateral or bilateral Renal Artery Stenosis.
• Hyperkalemia.

Side Effects:

Commonly reported complaints (1% or greater), regardless of causality, include: headache, upper respiratory infection, asthenia, rhinitis, low extremity pain, diarrhea, edema, pharyngitis, but none of those was more frequent by at least 1% on perindopril than on placebo, urinary tract infection, abdominal pain, sleep disorders, chest pain, injury, parasthesia, nausea, rash, seasonal allergy, depression, abnormal ECG, ALT increase, tinnitus, vomiting, neck pain, male, sexual dysfunction, triglyceride increase, somnolence, joint pain, nervousness, myalgia, menstrual disorders, flatulence, and arthritis.

Packing:

Box of 1, 2, or 3 blisters, each blister contains 10 tablets.

Adwipril  is a product manufactured by Adwia Pharmaceuticals Industries. Adwia is a leading Egyptian company founded in 1984 with a mission to bring the latest technologies and the highest available know-how to the market. They are committed to innovation and care and have a proven track record of success. For more information about Adwia Pharmaceuticals Industries, please visit their website or contact them directly.