Navigating Domperidone SEDICO: A Comprehensive User Guide

Welcome to this comprehensive guide on Domperidone SEDICO – available in tablets, oral suspension, and suppositories. As a healthcare professional, my goal is to provide you with a clear understanding of the uses, benefits, suggested doses, and practical advice associated with this medication.

Uses and Benefits:

1. Conditions and Symptoms Targeted:

Domperidone SEDICO, a derivative of benzimidazole, boasts both prokinetic and antiemetic properties. The key uses include:

• Short-term Treatment of Nausea & Vomiting: Effective in managing nausea and vomiting of various origins, including functional, infectious, organic, or dietetic causes. It is also beneficial for symptoms induced by radiotherapy or drug therapy.
• Gastrointestinal Disorders: Addresses gastrointestinal disorders associated with delayed gastric emptying, gastro-oesophageal reflux, and oesophagitis.

2. Mechanism of Action:

• Dopaminergic Antagonist: Domperidone acts as a dopaminergic antagonist, leading to several effects:
  • Increases basal lower esophageal sphincter pressure.
  • Inhibits relaxation of the gastric fundus.
  • Enhances antral contractility.
  • Relaxes the pyloric sphincter.

3. Benefits:

• Prokinetic Properties: Improves gastric motility, aiding in the timely emptying of the stomach.
• Antiemetic Effects: Effectively combats nausea and vomiting, providing relief across a spectrum of causes.
• Well-Absorbed and Fast-Acting: Well-absorbed after oral administration with peak plasma levels achieved within 1 hour after rectal administration.

Suggested Doses:

1. Tablets:

• Nausea & Vomiting: Take 2 tablets 3-4 times daily.
• Gastrointestinal Disorders: Initially, 1 tablet 3 times daily, preferably 15-30 minutes before meals. If necessary, take 1 tablet before bedtime. Dosage can be doubled when required.

2. Oral Suspension:

• Adults: 10-20 ml, 3-4 times daily before meals and before bedtime (dose according to severity).
• Children: 2.5 - 5 ml per 10 kg body weight, 3-4 times daily before meals and bedtime (adjust dosage based on severity).

3. Suppositories:

• Adults: 30-60 mg every 4-8 hours.
• Children:
  • Up to 2 years: 1 suppository (10 mg) 2-4 times daily.
  • 2-4 years: 1 suppository (30 mg) twice daily.
  • 4-6 years: 1 suppository (30 mg) 3 times daily.
  • Over 6 years: 1 suppository (30 mg) 4 times daily.

Practical Advice and Guidance:

1. Potential Side Effects:

• Plasma Prolactin Concentrations: May be increased, leading to galactorrhea or gynecomastia.
• Central Effects: Extrapyramidal dystonic reactions or drowsiness.
• Reduced Libido: Monitor for changes in libido.
• Allergic Reactions: Occasional rashes and other allergic reactions.

2. Contraindications:

• Hypersensitivity: Contraindicated in patients with known hypersensitivity to Domperidone.
• Gastrointestinal Conditions: Avoid in cases of gastrointestinal hemorrhage, obstruction, or perforation.
• Prolactinoma: Contraindicated in patients with prolactin-releasing pituitary tumors.

3. Drug Interactions:

• Opioid Analgesics & Antimuscarinics: May antagonize the prokinetic effects of Domperidone.
• Bromocriptine: Domperidone may antagonize the hypoprolactinemic effect of Bromocriptine.

4. Precautions:

• Renal Insufficiency: Reduce dose frequency in patients with renal insufficiency.
• Parkinsonian Patients: In nausea and vomiting treatment, therapy may be continued for a maximum of 12 weeks.
• Concomitant Use with Antacids: If using antacids or antisecretory agents simultaneously, take them after meals, not simultaneously with Domperidone.

5. Pregnancy and Lactation:

• Use During Pregnancy: While animal studies show no teratogenic effects, use during the first trimester is justified by therapeutic benefit. No evidence of increased human malformations, but caution is advised.
• Lactation: Nursing is not recommended unless benefits outweigh potential risks. Safety during pregnancy and lactation not firmly established.

Conclusion:

In conclusion, Domperidone SEDICO is a versatile medication with uses ranging from managing nausea and vomiting to addressing gastrointestinal disorders. Understanding the suggested doses, potential side effects, and practical advice is crucial for optimizing its benefits while ensuring patient safety.

This guide serves as general information. For personalized advice, consult your healthcare provider. Empower yourself with knowledge to navigate the use of Domperidone SEDICO effectively.

 

   

     

About the Author

     

Dr. Ahmad Baker, PharmD

     

He is a senior pharmacist and health educator with extensive experience in the Middle East and North Africa region. Through his writing, Dr. Ahmad aims to empower communities by providing reliable, evidence-based health information. With expertise in clinical pharmacy and regulatory affairs, he strives to offer unique insights into healthcare and simplify complex medical concepts, making them accessible to everyone.

   

   

         

 

 

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The information provided in this blog is for educational purposes only and is not a substitute for professional medical advice. We do not guarantee the accuracy or completeness of information regarding medications or medical products, and official sources should be verified before making any decisions. By using this blog, you agree to assume personal responsibility for relying on the information provided.