Unlocking Vital Information: EREC® Tablets for Erectile Dysfunction
EREC® Tablets, each containing 100mg of Sildenafil, serve as a potent solution for erectile dysfunction. This comprehensive guide navigates through EREC®, covering its composition, mechanism of action, indications, dosages, contraindications, potential side effects, drug interactions, precautions, and storage guidelines.
Composition and Mechanism of Action
Composition:
- Each tablet contains 100mg Sildenafil.
Mechanism of Action:
- Sildenafil, a phosphodiesterase inhibitor, competitively inhibits phosphodiesterase enzyme type 5.
- Inhibition of this enzyme increases cyclic guanosine monophosphate (cGMP), a mediator of vasodilation, leading to relaxation of corpus cavernosal smooth muscles.
- Increased blood flow into cavernosal spaces results in heightened intra-cavernosal pressure, a key factor in achieving an erection.
Indications
Indication:
- Treatment of Erectile Dysfunction.
Dosages
Adult Dosage:
- Half tablet (50mg Sildenafil) orally before sexual activity.
- Can be taken anytime between half to four hours before sexual activity.
Dosage Range:
- 25mg to 100mg daily, with a maximum frequency of once daily.
Special Considerations:
- A 25mg dose for patients with hepatic impairment, severe renal failure, or age over 65.
Contraindications
Nitrates:
- Contraindicated in patients using organic nitrates due to potential hypotensive effects.
Cardiovascular Conditions:
- Caution advised for patients with preexisting cardiovascular diseases where sexual activity is inadvisable.
Vision Disturbances:
- Contraindicated in patients with retinal nerve atrophy or any vision disturbances.
Hypersensitivity:
- Avoid in case of hypersensitivity to Sildenafil or any tablet component.
Priapism:
- Immediate medical assistance needed for prolonged erection (>4 hours) or painful erection (>6 hours).
Side Effects
Body-Wide:
- Face edema, headache, photosensitivity reactions, allergic reactions, chest pain, visual changes, and transient increased brightness.
Cardiovascular:
- Angina, syncope, tachycardia, hypotension, heart failure, flushing.
Hematologic & Musculoskeletal:
- Anemia, leukopenia, myalgia, arthritis, tendon rupture.
Neurological:
- Tremor, vertigo, depression, insomnia, abnormal dreams, ataxia.
Dermatologic:
- Urticaria, pruritus, sweating, skin ulcer, contact dermatitis.
Special Senses:
- Mydriasis, conjunctivitis, deafness, eye hemorrhage, cataract, dry eye.
Digestive & Genitourinary:
- Vomiting, dysphagia, gastritis, urinary frequency, breast enlargement, abnormal ejaculation.
Drug-Drug Interactions
- Interacts with Cimetidine, erythromycin, ketoconazole, itraconazole, ritonavir, darunavir, increasing Sildenafil levels.
- Rifampicin decreases Sildenafil serum level.
Precautions
Use with caution in patients with:
- Recent cardiovascular events.
- Resting hypotension or hypertension.
- Cardiac failure or coronary artery disease.
- Anatomical deformation of the penis.
- Sickle cell anemia, multiple myeloma, or leukemia.
- Retinitis pigmentosa.
- Bleeding disorders or active peptic ulceration.
Storage and Packaging
- Store below 30°C, away from direct sunlight, and out of reach of children.
- Packaging: Boxes containing 1, 3, 25, 50, or 100 strips, each with 1, 2, or 4 tablets and an insert.
Conclusion
EREC® Tablets with Sildenafil 100mg offer a targeted solution for erectile dysfunction. Medical practitioners are urged to follow recommended dosages, consider contraindications, and monitor potential side effects, ensuring optimal patient safety and efficacy.
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