Agiolax Granules: A Laxative for Constipation

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Agiolax Granules is a traditional medicine that is used for constipation. It contains two active ingredients: psyllium and senna. Psyllium is a bulk-forming laxative that works by absorbing water and increasing the size of the stool. Senna is a stimulant laxative that works by increasing the movement of the bowels.

Indications

Agiolax Granules is indicated for the relief of occasional constipation. It is not indicated for chronic constipation or for constipation that is caused by other medical conditions.

Dosage and Administration

The recommended dosage for adults and children over 10 years of age is 1-2 teaspoonsful of granules after the evening meal. The granules should be swallowed whole with an abundant amount of liquid (e.g., ¼ liter). When taking other medication, wait ½-1 hour before taking Agiolax.

Overdosage

In the event of an overdose, painful intestinal spasms and severe diarrhea with water and electrolyte losses may occur. If you think you have taken too much Agiolax, contact your doctor or pharmacist immediately.

Contraindications

Agiolax Granules is contraindicated in patients with the following conditions:

  • Abnormal stenoses in the gastrointestinal tract
  • Ileus
  • Diabetes mellitus that is difficult to control
  • Acute inflammatory intestinal diseases (e.g., Crohn's disease, ulcerative colitis)
  • Appendicitis
  • Abdominal pain of unknown cause
  • Severe dehydration with water and electrolyte losses
  • Children under 10 years of age

Special Precautions

  • Use of Agiolax Granules for longer periods of time may worsen any existing bowel sluggishness.
  • The preparation should only be used if constipation cannot be remedied by a change in diet or with the aid of bulking agents.
  • When Agiolax Granules is taken by adult incontinent persons, prolonged contact of the skin with the feces should be avoided by changing the sanitary towels.

Use in Pregnancy and Lactation

Agiolax Granules should only be used in pregnancy if constipation cannot be remedied by a change in diet or with the aid of bulking agents. Degradation products of senna pods with a laxative action (e.g., rhein) pass in small amounts into the maternal milk. No laxative effect on breastfed babies was observed.

Side Effects

The following side effects may occur with Agiolax Granules:

  • Spasmodic gastrointestinal complaints (very rarely)
  • Harmless red colouring of the urine
  • Water and electrolyte balance disorders (after long-term use or higher doses)
  • Potassium loss (may cause cardiac function disorders and myasthenia)
  • Albumin or blood in the urine (in cases of chronic use)
  • Staining of the intestinal mucosa (pseudomelanosis coli) (reversible after discontinuation of Agiolax)
  • Hypersensitivity reactions to Plantago ovata (very seldom)

Drug Interactions

  • In cases of chronic use or abuse, the loss of potassium can potentiate the effect of cardiac glycosides and influence the action of antiarrhythmics.
  • Loss of potassium can be enhanced in combination with certain diuretics, cortisone or cortisone-like substances (adrenocortical steroids) and liquorice roots.
  • The absorption of concurrently administered drugs from the gastrointestinal tract into the blood stream can be delayed.
  • A reduction of the insulin dose can be required in insulin-dependent diabetics.

Storage

Store Agiolax Granules below 30°C.

Shelf-Life: 3 years.

MIMS Class

Laxatives, Purgatives

ATC Classification

A06AB56 - senna glycosides, combinations ; Belongs to the class of contact laxatives.

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